It's impossible to describe Nikki Glaser's comedy without reference to Sarah Silverman, whose influence on the 26-year-old blonde from Kirkwood is blatant (both skip gleefully into the taboo pastures of rape and abortion). But while Silverman assumes the persona of the naive boor in order to lampoon A-listers and all things PC, Glaser offers a different emphasis: She sounds like a sweet sorority girl relishing her own depravity. ("Before I used my vibrator, I used my electric toothbrush.... Don't judge me! My vagina had never been whiter or more tartar-free.") Last year she landed a slot on Leno; more recently she appeared in the documentary I Am Comic alongside the art form's heavyweights. Rumor has it Glaser has developed some new material concerning her female parts that recently destroyed the Wednesday-night crowd down in Brennan's basement (4659 Maryland Avenue; 314-361-9444). May she continue to climb upward in her race to the bottom. That's how we like her best.