The season will be Nov. 15 to Jan. 31.
Biologist Jeff Beringer estimated the state's otter population at 15,000.
Trapping is the preferred "management tool" because it causes less damage to pelts, which can fetch about $30 each.
Missouri began its 10-year otter restoration program in 1982, releasing otters at 45 locations. But otters have taken a big bite out of the state's fisheries. Fishermen in the Ozarks have blamed otters for fewer smallmouth bass.